Purchase of Mass Spectrometers

Purchase of Mass Spectrometers

We are interested in acquiring a range of mass spectrometry and associated separation systems with ancillary equipment to enhance the University of Southampton”s analytical capability in the areas of proteomic, metabolomics and lipidomic research.

United Kingdom-Southampton: Mass spectrometer

2014/S 250-444400

Contract notice

Supplies

Directive 2004/18/EC

Section I: Contracting authority

I.1)Name, addresses and contact point(s)

University of Southampton
Highfield Road
Contact point(s): https://in-tendhost.co.uk/universityofsouthampton
For the attention of: John Davidson
SO17 1BJ Southampton
UNITED KINGDOM
Telephone: +44 2380594088
E-mail: jdav@soton.ac.uk

Internet address(es):

General address of the contracting authority: https://in-tendhost.co.uk/universityofsouthampton/

Address of the buyer profile: https://in-tendhost.co.uk/universityofsouthampton/

Further information can be obtained from: The above mentioned contact point(s)

Specifications and additional documents (including documents for competitive dialogue and a dynamic purchasing system) can be obtained from: The above mentioned contact point(s)

Tenders or requests to participate must be sent to: The above mentioned contact point(s)

I.2)Type of the contracting authority

Body governed by public law

I.3)Main activity

Education

I.4)Contract award on behalf of other contracting authorities

The contracting authority is purchasing on behalf of other contracting authorities: no

Section II: Object of the contract

II.1)Description

II.1.1)Title attributed to the contract by the contracting authority:

Mass Spectrometers x 6.

II.1.2)Type of contract and location of works, place of delivery or of performance

Supplies
Purchase

NUTS code UKJ32

II.1.3)Information about a public contract, a framework agreement or a dynamic purchasing system (DPS)

The notice involves a public contract
II.1.4)Information on framework agreement

II.1.5)Short description of the contract or purchase(s)

We are interested in acquiring a range of mass spectrometry and associated separation systems with ancillary equipment to enhance the University of Southampton”s analytical capability in the areas of proteomic, metabolomics and lipidomic research. These instruments will be integrated into current facilities and will be used to expand the breadth of analytical capabilities currently at the University and stimulate new research ties across multiple University campuses and other collaborating institutions.
To help bidders assess if the work is right for them, the following high level evaluation areas are:
Cost of equipment hardware and software 30 %
Technical evaluation 50 %
Service level agreement 15 %
Warranties 5 %.

II.1.6)Common procurement vocabulary (CPV)

38433100

II.1.7)Information about Government Procurement Agreement (GPA)

The contract is covered by the Government Procurement Agreement (GPA): no

II.1.8)Lots

This contract is divided into lots: yes
Tenders may be submitted for one or more lots

II.1.9)Information about variants

Variants will be accepted: yes
II.2)Quantity or scope of the contract

II.2.1)Total quantity or scope:

The instruments are:
A: High Resolution LC-MS/MS system with 2D – nanoUPLC – Application: Proteomics
B: High Resolution LC-MS/MS system with 1D – nanoUPLC – Application: Proteomics
C: High Resolution mass spectrometer — Application: Proteomics
D: High Resolution MS with MALDI imaging capability and Supercritical Fluid Chromatography system – Application: Metabolomics/Lipidomics
E: High sensitivity triple quadrupole MS with UPLC — Application: Metabolomics/Lipidomics
F: Low Mass, High Resolution Mass Spectrometer for trace gas analysis — Application: Volatile Metabolomics.
II.2.2)Information about options
II.2.3)Information about renewals

II.3)Duration of the contract or time limit for completion

Duration in months: 36 (from the award of the contract)

Information about lots

Lot No: 1Lot title: High Resolution LC-MS/MS system with 2D – nano UPLC – Application: Proteomics

1)Short description

The Purpose of the Equipment
To provide high selectivity and sensitivity for proteomic applications within the Centre for Proteomic Research, including peptide/protein biomarker identification, characterisation of post-translational modifications, and quantitative approaches such as iTRAQ, TMT, SILAC and label-free analyses using data dependent and data independent modes of acquisition. The instrument will also be used for targeted multiple reaction monitoring experiments.
Complete quaternary 2D- nanoUPLC system, with open-bed well plate autosampler, column oven and solvent delivery of 50 nl to 100 ?l/min. The system should allow the direct loading and trapping of sample onto the analytical column. The flow path should be biocompatible for the analysis of biomolecules such as phosphopeptides.
The mass-spectrometer requirements are:
High resolution, Quadrupole, Time of Flight/ Ion-trap type instrument, with ESI and nanoESI sources. These sources should be able to be exchanged on a short time scale (~5 min).

2)Common procurement vocabulary (CPV)

38433100

3)Quantity or scope

The mass-spectrometer requirements are:
High resolution, Quadrupole, Time of Flight/ Ion-trap type instrument, with ESI and nanoESI sources. These sources should be able to be exchanged on a short time scale (~5 min).
Auxiliary equipment
Nitrogen generator (No Air compressor required).
Chiller units, if required.
Required Software
Software to operate, test and control all hardware systems, software for all data collection and reduction operations, software to control unattended multiple sample analysis, software to store and archive all instrument parameters and acquired data for ISO:9001 quality control purposes. Software and hardware for database searching and the analysis of label-free (using both Data Dependent and Data Independent modes of acquisition) and label based (iTRAQ, TMT, SILAC) quantitative proteomic approaches is required so that analysis can be performed across 4 sites. The should be at least one standalone PC workstation for data processing.
Estimated value excluding VAT:
Range: between 300 000 and 500 000 GBP
4)Indication about different date for duration of contract or starting/completion
5)Additional information about lots

Lot No: 2Lot title: High Resolution Mass Spectrometer with 1D-nanoUPLC

1)Short description

The Purpose of the Equipment
To provide high selectivity and sensitivity for proteomic applications within the Centre for Proteomic Research, including peptide/protein biomarker identification, phosphopeptide analysis, and quantitative approaches such as iTRAQ, TMT, SILAC and label-free analyses using data dependent and data independent modes of acquisition. The instrument will also be used for targeted multiple reaction monitoring experiments and intact protein measurements in deuterium hydrogen exchange experiments.
1D nanoUPLC with open-bed well plate autosampler, column oven and solvent delivery of 50 nl to 100 ?l/min. The system should allow the direct loading and trapping of sample onto the analytical column. The flow path should be biocompatible for the analysis of biomolecules such as phosphopeptides.

2)Common procurement vocabulary (CPV)

38433100

3)Quantity or scope

The mass-spectrometer requirements are:
High resolution, Quadrupole, Time of Flight/ Ion-trap type instrument, with ESI and nanoESI sources. These sources should be able to be exchanged on a short time scale (~5 min).
Minimum mass range m/z ? 50 to ? 100,000 (ESI or nESI mode)
Minimum mass range (Quadrupole) m/z ? 50 to ? 4,000 (ESI mode)
High sensitivity full scan MS and MS/MS with a resolution of ? 40,000 @ m/z 400 at an acquisition speed ? 3 Hz
Mass accuracy: ? 3 ppm RMS with external calibration; ? 2 ppm RMS with internal calibration.
LC-MS/MS Sensitivity (with nESI): ? 50 fmol/uL BSA tryptic peptide digest at ? 40 % peptide sequence coverage at optimum mass accuracy and resolution settings.
Dynamic response range: 4 orders of magnitude
Ion mobility is desirable
Auxillary equipment
Nitrogen generator (No Air compressor required).
Chiller units, if required.
Required Software
Software to operate, test and control all hardware systems, software for all data collection and reduction operations, software to control unattended multiple sample analysis, software to store and archive all instrument parameters and acquired data for ISO:9001 quality control purposes. Software and required hardware for the analysis of label-free (using both Data Dependent and Data Independent modes of acquisition), or label based (iTRAQ, TMT, SILAC) quantitative proteomic approaches and protein de-convolution should be provided.
Estimated value excluding VAT:
Range: between 150 000 and 350 000 GBP
4)Indication about different date for duration of contract or starting/completion
5)Additional information about lots

Lot No: 3Lot title: High Resolution Mass Spectrometer

1)Short description

The Purpose of the Equipment
To provide high selectivity and sensitivity for proteomic applications with a focus on peptide/protein biomarker identification using label-free analyses (with both data dependent and data independent modes of acquisition). The instrument should offer ion mobility separation. The instrument will also be used for targeted multiple reaction monitoring experiments and intact protein measurements in deuterium hydrogen exchange experiments.

2)Common procurement vocabulary (CPV)

38433100

3)Quantity or scope

Primary Hardware
The mass-spectrometer requirements are:
High-resolution, Quadrupole, Time of Flight/ Ion-trap type instrument, with ion mobility and nanoESI source.
Minimum mass range m/z ? 50 to ? 100,000 (ESI mode)
High sensitivity full scan MS and MS/MS with a resolution of ? 30,000 @ m/z 400 at an acquisition speed ? 3 Hz
Minimum mass range (Quadrupole) m/z ? 50 to ? 4,000 (ESI mode)
Mass accuracy: ? 3 ppm RMS with external calibration; ? 2 ppm RMS with internal calibration.
LC-MS/MS Sensitivity (with nESI): ? 50 fmol/uL BSA tryptic peptide digest at ? 40 % peptide sequence coverage at optimum mass accuracy and resolution settings.
Dynamic response range: 4 orders of magnitude
Ion mobility is desirable
Auxillary equipment
Nitrogen generator (No Air compressor required).
Chiller units, if required.
Required Software
Software to operate, test and control all hardware systems, software for all data collection and reduction operations, software to control unattended multiple sample analysis, software to store and archive all instrument parameters and acquired data for ISO:9001 quality control purposes. Software and required hardware for the analysis of label-free data (using both Data Dependent and Data Independent modes of acquisition). The generated outputs from the software (which must include the parameters retention time, ion mobility drift time, mass-to-charge ratio and intensity) will need to be in a format compatible with algorithms and software written by the client. If the software outputs are not directly compatible, the vendor will be required to write the necessary software to do so.
Estimated value excluding VAT:
Range: between 150 000 and 300 000 GBP
4)Indication about different date for duration of contract or starting/completion
5)Additional information about lots

Lot No: 4Lot title: High Resolution Mass Spectrometer with MALDI imaging capabilities and supercritical fluid chromatography system

1)Short description

The Purpose of the Equipment
To provide an enhanced, state-of-the art mass spectrometry (MS) capacity with high selectivity and sensitivity for lipidomic and metabolomic analysis to support the needs of the Faculty of Medicine (FoM), University of Southampton and the Southampton Centre for Biomedical Research (SCBR) Southampton General Hospital, Southampton. The instrument should provide both data dependent and data independent modes of acquisition; and MALDI imaging capability. Ion mobility capability is also desirable.

2)Common procurement vocabulary (CPV)

38433100

3)Quantity or scope

Primary Hardware
SFC chromatography system with autosampler, column oven and solvent delivery of xx to xx ?l/min.
The mass-spectrometer requirements are:
High resolution, Quadrupole, Time of Flight/ Ion-trap type instrument with ESI
Minimum mass range (Quadrupole) m/z ? 50 to ? 4,000 (ESI mode)
High sensitivity full scan MS and MS/MS with a resolution of ? 30,000 @ m/z 400 at an acquisition speed ? 3 Hz
Mass accuracy: ? 3 ppm RMS with external calibration; ? 2 ppm RMS with internal calibration.
Good comparative signal intensity between positive and negative ionisation modes.
LC-MS/MS Sensitivity (with SFC): attogram sensitivity
Dynamic response range: 4 orders of magnitude
The instrument should have a MALDI ionisation source to provide imaging capability.
Ion mobility is desirable
Auxillary equipment
Nitrogen generator (No Air compressor required).
Chiller units, if required.
Required Software
Software to operate, test and control all hardware systems, software for all data collection and reduction operations, software to control unattended multiple sample analysis, software to store and archive all instrument parameters and acquired data for ISO:9001 quality control purposes.
Estimated value excluding VAT:
Range: between 150 000 and 300 000 GBP
4)Indication about different date for duration of contract or starting/completion
5)Additional information about lots

Lot No: 5Lot title: High sensitivity triple quadrupole MS with UPLC

1)Short description

The Purpose of the Equipment
To provide an enhanced, state-of-the art mass spectrometry (MS) capacity with high selectivity and sensitivity for lipidomic and metabolomic analysis to support the needs of FoM, UoS and SCBR.

2)Common procurement vocabulary (CPV)

38433100

3)Quantity or scope

The mass-spectrometer requirements are:
High sensitivity Triple Quadrupole instrument, with ESI and APPI sources. These sources should be able to be exchanged on a short time scale (~5 min).
Minimum mass range m/z ? 50 to ? 4,000 (ESI or APPI mode)
High sensitivity full scan MS and MS/MS.
Rapid positive/negative ionisation switching with minimal loss of performance.
Good comparative signal intensity between positive and negative ionisation modes.
LC-MS/MS Sensitivity – attogram sensitivity
Dynamic response range: 5 orders of magnitude
Auxillary equipment
Nitrogen generator (No Air compressor required).
Chiller units, if required.
Required Software
Software to operate, test and control all hardware systems, software for all data collection and reduction operations, software to control unattended multiple sample analysis, software to store and archive all instrument parameters and acquired data for ISO:9001 quality control purposes.
Estimated value excluding VAT:
Range: between 50 000 and 300 000 GBP
4)Indication about different date for duration of contract or starting/completion
5)Additional information about lots

Lot No: 6Lot title: Low Mass, High Resolution Mass Spectrometer for trace gas analysis

1)Short description

The Purpose of the Equipment
To provide state-of-the art mass spectrometry (MS) capability with high selectivity and sensitivity for metabolomic analysis of low mass volatiles (exhaled breath, skin emanations, environmental gasses) to support the needs of the Faculty of Medicine (FoM), University of Southampton and the Southampton Centre for Biomedical Research (SCBR) Southampton General Hospital, Southampton. The instrument should provide electron impact (EI) ionization and atmospheric pressure chemical ionization (APCI) capability for maximum flexibility and sensitivity.

2)Common procurement vocabulary (CPV)

38433100

3)Quantity or scope

The Purpose of the Equipment
To provide state-of-the art mass spectrometry (MS) capability with high selectivity and sensitivity for metabolomic analysis of low mass volatiles (exhaled breath, skin emanations, environmental gasses) to support the needs of the Faculty of Medicine (FoM), University of Southampton and the Southampton Centre for Biomedical Research (SCBR) Southampton General Hospital, Southampton. The instrument should provide electron impact (EI) ionization and atmospheric pressure chemical ionization (APCI) capability for maximum flexibility and sensitivity.
Primary Hardware
Dual source high-performance triple quadrupole mass spectrometer for low m/z range.
The mass-spectrometer requirements are:
High resolution, Triple Quadrupole type instrument with combined ESI (membrane inlet option) and APCI source
Minimum mass range m/z 1-120
High sensitivity full scan MS with a resolution of ? 2,500 (M/deltaM FWHM)
MS Sensitivity (with APCI source) for nitric oxide (NO): ?5 ppt
Minimum dynamic response range: 5 orders of magnitude
Auxillary equipment
Nitrogen generator (no air compressor required)
Cryofocussing unit for sample preconcentration
Required Software
Software to operate, test and control all hardware systems, software for all data acquisition operations, software to control unattended multiple sample analysis, software to store and archive all instrument parameters and acquired data for ISO:9001 quality control purposes.
Estimated value excluding VAT:
Range: between 150 000 and 300 000 GBP
4)Indication about different date for duration of contract or starting/completion
5)Additional information about lots

Section III: Legal, economic, financial and technical information

III.1)Conditions relating to the contract

III.1.1)Deposits and guarantees required:

The Contracting Authority reserves the right to require deposits, guarantees, bonds, warranties and other forms of appropriate security.

III.1.2)Main financing conditions and payment arrangements and/or reference to the relevant provisions governing them:

As defined in the Tender Documents.

III.1.3)Legal form to be taken by the group of economic operators to whom the contract is to be awarded:

No special legal form will be required. In the case of organisations applying as a consortia or joint venture, full details for each member is required. It will be necessary for each member to sign an undertaking that they shall be jointly and severally liable, or to require a single provider to take primary liability for the performance of the contract.
III.1.4)Other particular conditions
III.2)Conditions for participation
III.2.1)Personal situation of economic operators, including requirements relating to enrolment on professional or trade registers

III.2.2)Economic and financial ability

Information and formalities necessary for evaluating if the requirements are met: In accordance with Articles 43 to 51 of Directive 2004/18/EC as amended by S.I. 2007/2157, 2009/2992,2011/1441; and Regulation 24 of the Public Contracts Regulations 2006 as amended by The Public Contracts (Amendment) Regulations 2009.
To support the financial assessment the University will obtain a financial appraisal report from Creditsafe. This report provides the University with an overall Risk Score which will be used to assess the applicants financial standing. A suitable Performance Bond or Parent Company Guarantee may at the University’s discretion be accepted and allowed to override a poor credit score.
Minimum level(s) of standards possibly required: Organisations are advised that the following insurance levels are usually required:
— Employers Liability 10 000 000 GBP;
— Public Liability 10 000 000 GBP;
— Professional Indemnity 5 000 000 GBP.

III.2.3)Technical capacity

Minimum level(s) of standards possibly required:
British, CE or equivalent Health, Safety and Environmental standards must be met.
III.2.4)Information about reserved contracts
III.3)Conditions specific to services contracts
III.3.1)Information about a particular profession
III.3.2)Staff responsible for the execution of the service

Section IV: Procedure

IV.1)Type of procedure

IV.1.1)Type of procedure

Open
IV.1.2)Limitations on the number of operators who will be invited to tender or to participate
IV.1.3)Reduction of the number of operators during the negotiation or dialogue
IV.2)Award criteria

IV.2.1)Award criteria

The most economically advantageous tender in terms of the criteria stated in the specifications, in the invitation to tender or to negotiate or in the descriptive document

IV.2.2)Information about electronic auction

An electronic auction will be used: no
IV.3)Administrative information

IV.3.1)File reference number attributed by the contracting authority:

14/ESM/91

IV.3.2)Previous publication(s) concerning the same contract

no

IV.3.3)Conditions for obtaining specifications and additional documents or descriptive document

Time limit for receipt of requests for documents or for accessing documents: 9.2.2015 – 12:00
Payable documents: no

IV.3.4)Time limit for receipt of tenders or requests to participate

10.2.2015 – 12:00
IV.3.5)Date of dispatch of invitations to tender or to participate to selected candidates

IV.3.6)Language(s) in which tenders or requests to participate may be drawn up

English.

IV.3.7)Minimum time frame during which the tenderer must maintain the tender

in days: 90 (from the date stated for receipt of tender)
IV.3.8)Conditions for opening of tenders

Section VI: Complementary information

VI.1)Information about recurrence

VI.2)Information about European Union funds

The contract is related to a project and/or programme financed by European Union funds: no

VI.3)Additional information

This tender will be conducted electronically and tender documents can be downloaded from the web portal (Intend) provided earlier in this notice.https://in-tendhost.co.uk/universityofsouthampton

If you are not already registered as a supplier with the In-tend Portal, you will need to register before accessing the tender documents. if you are not an existing supplier to the University, please complete and upload the Health and Safety New Supplier documentation which is attached to the stage along with the tender document.
Once you have logged in as a supplier, click on current tenders and locate the tender documents by clicking on 14/ESM/91. Further instructions for the submission of tender are below. (Please note, to preserve the integrity of the tendering procedure, all queries must made be via In-Tend).
1 Completion of Tender
1.1 Offers will be considered for all or part of the contract.
1.2 The system will only permit you to submit one return. You may upload as many documents as necessary but once your return has been submitted no further documents can be uploaded.
1.3 The most efficient method to upload your submission is to create a Zip File containing all necessary documents and upload the zip file.
1.4 Your tender response must be submitted through the — Submit My Return — facility in In-tend which is accessed via the — My Tenders — icon, do NOT use the correspondence facility or a standard email. To submit your return, please follow the instructions below:
1. Log In.
2. My Tenders.
3. View Tender Details.
4. View Documents.
5. Browse and Upload each part of your return (or Zip File).
6. Once ALL your response documents are uploaded and displayed in the — My Documents for Return — use — Submit My Return — . You are only permitted to submit once.

VI.4)Procedures for appeal
VI.4.1)Body responsible for appeal procedures
VI.4.2)Lodging of appeals
VI.4.3)Service from which information about the lodging of appeals may be obtained

VI.5)Date of dispatch of this notice:

24.12.2014

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